Zebrafish is gaining prominence as an important vertebrate model for investigating various human diseases such as neurodegenerative disease, cancer and chronic inflammatory diseases. Zebrafish provides unique advantages, for example optical clarity of embryos, high fecundity rate, and low cost of maintenance, making it a perfect complement to the murine model in biomedical research. Recent advances, which includes the generation of novel transgenic lines that enable real time imaging of neuronal activities, the use of cancer cell line or tissue xenotransplantation techniques, and the development of efficient knock-out/knock-in technologies, now allow the detailed investigation of human disease in zebrafish. The objective of this meeting is to provide a platform for Malaysian investigators, postdocs and students working or planning to work in the zebrafish field to learn the latest developments in zebrafish as a model for human disease, to present data and share their techniques, and to have the opportunity to interact with international and local experts in the field of biomedical research using zebrafish